P219 Mucosal healing and histological remission in paediatric ulcerative colitis: Does the target change the outcomes?

Controversies in mucosal healing in ulcerative colitis.

As clinicians we would all agree that the goal for our patients is to induce remission, which is usually defined as symptom resolution. Restoring continence and absence of rectal bleeding would be signs that the mucosa is at most minimally inflamed if not healed. However, there have not been any data to confirm that symptomatic improvement alters the natural history of the disease, nor decrease...

Mucosal Healing in Ulcerative Colitis – the Fountain of Youth?

Can histologic remission be a better prognostic factor and therapeutic target beyond endoscopic mucosal healing in patients with ulcerative colitis?

Clinical Study of the Relation between Mucosal Healing and Long-Term Outcomes in Ulcerative Colitis

Background and Objectives. Mucosal healing (MH) is considered an important therapeutic goal in ulcerative colitis (UC). We evaluate the severity of intestinal inflammation and clarify the relation between MH and long-term outcomes. Methods. The study group comprised 38 patients with UC in clinical remission on total colonoscopy who were followed up for at least 5 years. Clinical remission was d...

Endomicroscopy for assessing mucosal healing in patients with ulcerative colitis.

The assessment of tissue healing has emerged as an important treatment goal in patients with inflammatory bowel disease. In patients with ulcerative colitis (UC), mucosal healing may represent the ultimate therapeutic goal due to the fact that the inflammation is limited to the mucosal layer. Mucosal and histological healing may indicate a subset of UC patients in long-term clinical, endoscopic...